The results showed that the overexpression of HAI-2 suppresses the migration and invasion of human prostate cancer cells (Figs 2 and 7), while the treatment of purified recombinant HAI-2 (rHAI-2) proteins is only able to repress prostate cell invasion without any effect on migration (Figs 4C,D and 8C,D). Here, SPINT2 is linked to prostate cancer.