SPINT2 and Familial prostate cancer: A growing body of evidence further regards HAI-2 as a tumor suppressor, and its down-regulation is linked to poor prognosis in various cancers, including hepatocellular carcinoma, melanoma, esophageal squamous cell carcinoma, gastric cancer, renal cell carcinoma, prostate cancer, cervical cancer, medulloblastoma and ovarian cancer58–68.