From our previous studies, we know that ADAM9 allows lung cancer cells in an anchorage-free state to circumvent anoikis by (i) up-regulating the activity of the pro-migratory CUB domain-containing protein-1 (CDCP1) via cleavage by tissue plasminogen activator (tPA, PLAT) and (ii) reciprocally decreasing expression of plasminogen activator inhibitor 1 (PAI-1, SERPINE1)14. Here, CDCP1 is linked to lung cancer.