To determine whether high levels of ADAM9-regulated ANGPT2 and VEGFA in lung adenocarcinoma patients are clinically relevant in terms of prognosis, we analyzed three lung cancer datasets (Asia population: GSE8894 and GSE11969; Western population: Shedden dataset) using a Cox proportional hazards regression model19–21. This evidence concerns the gene ANGPT2 and lung adenocarcinoma.