TGFB1 and hepatocellular carcinoma: The level of DNMT1 was higher after treatment of the hepatocellular carcinoma cell lines with an mTOR inhibitor, Torin-2, whereas the increase in DNMT1expression by TGF-β treatment was abolished in fibroblasts by FAK, PI3K, and mTOR inhibitors, including rapamycin37,38.