AKT1 and lung cancer: We then isolated lung cancer cells from KRas;rank+/+ and KRas;rankfl/fl mice using RANKL induction of PGC1β as a readout (Supplemental Fig. S7B); inhibition of AKT and NF-κB, but not of p38, abrogated RANK-mediated PGC1β induction (Supplemental Fig. S7C).