TNFRSF11A and neoplasm: Interference with mitochondrial respiration using oligomycin at doses used previously in vitro and in vivo to block OXPHOS (Viale et al. 2014) indeed resulted in markedly reduced numbers of tumor spheroids in both control and RANKL-stimulated KRas;rank+/+ cells in a dose-dependent fashion (Fig. 6C,D).