We next analyzed 120 human lung tissue samples of non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) and detected strong tumoral RANK expression in each lung cancer histotype; the incidence and intensity of expression were greatest in adenocarcinomas, with 72% of lung adenocarcinomas staining positive for RANK (Fig. 1A; Supplemental Fig. S1A). This evidence concerns the gene TNFRSF11A and small cell lung carcinoma.