To explore the molecular mechanisms of how RANKL/RANK might affect the growth of lung cancer cells, we first isolated primary pneumocytes from KRas;rank+/+ and KRas;rankfl/fl mice and infected them with AdCre to knock out RANK and at the same time induce oncogenic KRasG12D (Supplemental Fig. S5A). This evidence concerns the gene TNFSF11 and lung cancer.