Expression data were confirmed in a second independent lung cancer cohort (Graz cohort, n = 60) (Supplemental Fig. S1D) and a third tumor tissue microarray panel of 354 individual patient samples from primarily early stage treatment-naive resected NSCLC (“Uppsala” cohort) (Botling et al. 2013), with both showing frequencies of RANK expression within lung cancer histotypes similar to that observed with the patient surveys in Supplemental Figure 1A. The gene discussed is TNFRSF11A; the disease is lung cancer.