TNFRSF11A and lung carcinoma: To test whether our findings on the effects of RANK on OXPHOS extend to human lung cancer, we assayed mitochondrial bioenergetics in four human lung cancer cell lines; namely, in the two RANKhigh-expressing cell lines A427 and H1437 and the two RANKlow-expressing cell lines H460 and H2122 (Supplemental Fig. S6C).