Similarly to our data on murine primary pneumocytes and purified lung cancer cells, we observed a significant increase in mitochondrial respiration in A427 and H1437 cells upon RANK activation, whereas we did not find a significant change in the RANKlow H460 and H2122 human lung cancer cells (Fig. 5E; Supplemental Fig. S6D). This evidence concerns the gene TNFRSF11A and lung carcinoma.