In fact, culture assays and xenograft of fibrosarcoma HT1080 cells have shown that fibronectin is endocytosed and re-secreted from a late endosomal/lysosomal compartment to provide an autocrine ECM substrate to enhance directional migration (Sung and Weaver, 2011, Sung et al., 2015). The gene discussed is FN1; the disease is fibrosarcoma.