We selected fructose‐1,6‐bisphosphatase 1, FBP1, encoding the gluconeogenesis regulatory enzyme, acting as a rate‐limiting enzyme in gluconeogenesis and a well‐known tumor suppressor in HCC (Hirata et al., 2016; Wang et al., 2014), and fibroblast growth factor 1, FGF1, encoding a well‐known pro‐oncogenic growth factor in HCC (Lee et al., 2015; Yang et al., 2017). This evidence concerns the gene FBP1 and hepatocellular carcinoma.