Variants in THADA have been associated with age-related hearing impairment[44], Crohn's disease[45], DNA methylation variation[46], hair morphology[47], inflammatory bowel disease[48], mitochondrial DNA levels[49], orofacial clefts[50,51], platelet counts[52], polycystic ovary syndrome[53,54], prostate cancer[55], response to amphetamines[56], and type 2 diabetes[57]. The gene discussed is THADA; the disease is inflammatory bowel disease.