Along these lines, Popova et al., demonstrate a reduced chemotaxis of pulmonary mesenchymal cells isolated from BPD patients with reduced mRNA levels for PDGF-Rα [16], that is in concert with studies performed on ventilated newborn mice and lamb connecting dysregulated PDGF-A and PDGF-Rα signaling to disease development [17–20]. This evidence concerns the gene PDGFRA and bronchopulmonary dysplasia.