To determine the global levels of H2A.Zac and relationship with prognosis we performed immunohistochemistry in tissue microarrays from high risk localized prostate cancer cases, using an antibody that recognizes H2A.Z acetyl K4+K7+K114 (Supplementary Table 1, Supplementary Fig. 1a–c, Fig. 1a). The gene discussed is KRT4; the disease is Familial prostate cancer.