To further address a pro-oncogenic role of H2A.Zac in prostate cancer, we generated a doxycycline inducible cell model in the prostatic adenocarcinoma cell line LNCaP that expresses a mutant form of H2A.Z-1, whereby the three most commonly acetylated lysines (K4, K7, and K11)6, 12 have been replaced by arginines (3R cells, Fig. 1d). Here, H2AZ1 is linked to Familial prostate cancer.