Notably the concordant epigenetic changes of H2A.Zac nucleosome occupancy, chromatin accessibility, DNA methylation and gene expression, were observed at promoters and enhancers of cancer-related genes that are overexpressed in LNCaP cells (Fig. 5a and Supplementary Fig. 4a) and in clinical prostate cancer, GREB1, TRPM8, KLK2, and KLK327. The gene discussed is KLK2; the disease is cancer.