The CXCL10/CXCR3 and CXCL13/CXCR5 axes are associated with disease activity in several autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and adult onset Still’s disease8–12. The gene discussed is CXCL13; the disease is systemic lupus erythematosus.