Serum levels of CXCL8 (mean ± SD 230 ± 1656, median 11 pg/ml vs. 57 ± 80, median 36 pg/ml, respectively; p = 0.001) CXCL10 (153 ± 118, median 127 pg/ml vs. 105 ± 72, median 90 pg/ml, respectively; p = 0.007) and CXCL12 (1771 ± 987, median 1656 pg/ml vs. 1234 ± 713, median 1086 pg/ml, respectively; p = 0.003) were significantly higher in blood collected at the time of initial evaluation from BD patients than HCs. This evidence concerns the gene CXCL8 and Behcet disease.