To determine if EphB6 increases drug sensitivity in T-ALL by supporting the induction of the apoptotic cell death, we monitored activation status of a key pro-apoptotic molecule, caspase-3 30, in ΔB6-Jurkat and pc3-Jurkat cells using the EnzChek Caspase-3 assay. This evidence concerns the gene EPHB6 and acute lymphoblastic leukemia.