On a molecular level, this effect is associated with the decrease in the activating phosphorylation of a pro-survival molecule, the Akt kinase and with reduced phosphorylation of its downstream target, the p70 S6 kinase, indicating that EphB6 acts by suppressing Akt signaling in doxorubicin-treated T-ALL cells. This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.