In order to explore the relevance for AQP3 in humans, we performed an immunofluorescence double staining of AQP3 and α-SMA of either healthy liver patient tissues (all fibrosis stage 0 and WT for PNPLA3, n = 4) or NASH patients with fibrosis stage 1c and 4 (n = 5 for PNPLA3 I148M, n = 5 for PNPLA3 WT). The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatohepatitis.