TP53 and cancer: Interestingly, the top 10 GO terms showed downregulated ISOs were mainly enriched in cell cycle (Fig. 4c), consistent with downregulated DE genes in ZIKV infected samples [6], while pathway analysis found downregulated ISOs were involved in cell cycle, p53 signaling pathway, pathways in cancer, pyrimidine metabolism, and progesterone-mediated oocyte maturation (Fig. 4d).