This may well explain the many previous reports that, under a variety of disease conditions, CLU occurs in cellular locations outside the secretory system, including the co-localization of CLU with intracellular tau tangles in Alzheimer’s disease [44], α-synuclein rich Lewy bodies in Parkinson’s disease [45], and inclusion bodies in myofibrillar myopathies [46]. This evidence concerns the gene CLU and early-onset autosomal dominant Alzheimer disease.