BRAF and colorectal cancer: In light of recent evidence that miR-193a-3p may have a tumor suppressive function in cancers of other organs, such as breast and lung [36, 37], and our finding that this miRNA was down-regulated in BRAF-mutant colorectal cancers (Figs. 1 and 2), we hypothesized that miR-193a-3p serves as a tumor-suppressive miRNA in colorectal cancer.