In HER-2 positive breast cancer, trastuzumab administered concurrently with chemotherapy has deeply modified the natural history of the disease by significantly improving response rates and survival in patients receiving chemotherapy and trastuzumab (CT + TR) compared to those receiving chemotherapy alone (CT) (median survival 25.1 months in CT + TR group versus 20.3 months in CT group, P 0.046) [3]. Here, ERBB2 is linked to breast carcinoma.