Klopfleisch et al. found the higher expression of CDC6, CCNE1, MYBL2, PDCD10, ERBB2IP, SON, STK4, CDC27, PRC1, CDC37, TTK, SKIL, BUB3 and SPIN1 in metastatic canine mammary cancer in comparison with non-metastatic canine mammary cancer [27]. The gene discussed is BUB3; the disease is breast cancer.