Klopfleisch et al. found the higher expression of CDC6, CCNE1, MYBL2, PDCD10, ERBB2IP, SON, STK4, CDC27, PRC1, CDC37, TTK, SKIL, BUB3 and SPIN1 in metastatic canine mammary cancer in comparison with non-metastatic canine mammary cancer [27]. This evidence concerns the gene CDC6 and breast cancer.