ACHE and Alzheimer disease: 2015). The resulting lack of cholinergic neurotransmission due to reduced ACh levels eventually leads to cognitive deficits and in the worst cases, death (Adewusi et al. 2011; Ali et al. 2015). Thus, therapies that inhibit AChE and thereby increase ACh levels are promising temporary treatments for AD (Sallam et al. 2016).