2015). The resulting lack of cholinergic neurotransmission due to reduced ACh levels eventually leads to cognitive deficits and in the worst cases, death (Adewusi et al. 2011; Ali et al. 2015). Thus, therapies that inhibit AChE and thereby increase ACh levels are promising temporary treatments for AD (Sallam et al. 2016). This evidence concerns the gene ACHE and Cognitive impairment.