KCTD5 and infection: Since we do not observe an increase in the ubiquitination of KCTD5 due to the infection with H. pylori, we cannot ruled out another ubiquitin-independent mechanism of proteolysis involved on the degradation of KCTD5 (Tofaris et al., 2001; Asher et al., 2005; Ben-Nissan and Sharon, 2014).