AD is associated with regional cerebral hypometabolism, extracellular Aβ plaques, intracellular neurofibrillary tangles (NFTs) containing hyperphosphorylated tau, neuroinflammation and oxidative stress, loss of synaptic connections, neural death and atrophy and resultant clinical manifestations of AD.4-7 The progressive accumulation of Aβ and NFT is believed to begin more than 15 (Aβ) to 10 (NFT) years prior to onset of clinical disease. This evidence concerns the gene MAPT and Alzheimer disease.