NP031112 (tideglusib), a non-ATP competitive GSK-3 inhibitor has been found to reduce p-tau and Aβ, prevent neuronal death and improve cognition in animals.76 Methylene blue (RemberTM), an anti-tau aggregate and anti-oxidant has also been found to improve cognition in patients with mild to moderate AD.77 This evidence concerns the gene MAPT and Alzheimer disease.