MAPK8 and Alport syndrome: JNK activation has also been identified in a diverse range of animal models of glomerular disease, including; crescentic glomerulonephritis, diabetic nephropathy, minimal change disease, Alport's syndrome, and salt-sensitive hypertension (Nishiyama et al., 2004; Park and Jeong, 2004; Flanc et al., 2007; Lim et al., 2011; Nakagawa et al., 2016).