The dysregulation of iron importers, including transferrin (Tf), divalent metal transporter 1 (DMT1), lactoferrin (Lf) and melanotransferrin (MTf), as well as iron exporter ferroportin (Fpn), may account for iron accumulation in the affected brain regions of AD patients (Figure 1). The gene discussed is SLC11A2; the disease is Alzheimer disease.