ATP13A2 and Lewy body dementia: Studies have shown that the over-expression of ATP13A2 reduces intracellular Mn concentration, which in turn, alleviates Mn-provoked lethality; loss-of-function mutations in ATP13A2 are correlated with increases in both α-synuclein and Aβ plaques in Lewy body disease (Murphy et al., 2013).