Furthermore, treatment with Mg sulfate reduces levels of hyper-phosphorylated tau by inhibiting GSK-3β phosphorylation and increasing the activity of protein kinase B (Akt) and phosphatidylinositol 3 kinase (PI3K) (Gomez-Ramos et al., 2006; Xu et al., 2014), thus suggesting that Mg acts as a neuroprotective factor in the development of AD. This evidence concerns the gene MAPT and Alzheimer disease.