Despite a great deal of debate surrounding the effectiveness of IPLEX (Bedlack et al., 2009; Gould and Oppenheim, 2011), clinical trial employing a delivery of VEGF protein into ALS patients CSF is currently in progress (http://clinicaltrials.gov, identifier # NCT01384162 and NCT008005501). This evidence concerns the gene VEGFA and amyotrophic lateral sclerosis.