Whilst brivanib (VEGFR/FGFR inhibitor) and the multi-kinase inhibitor pazopanib had no effect, both danusertib (a pan-aurora kinase inhibitor with an off-target effect on FGFR1) and ponatinib (a Src and Bcr-Abl kinase inhibitor with activity on all 4 FGFRs)24 reduced CCA cell viability. The gene discussed is FGFR1; the disease is cholangiocarcinoma.