Genomic screening of 410 key cancer genes using next-generation sequencing based MSKTM-IMPACT revealed somatic alterations in 3 important genes: PDGFRB, KMT2D and MPL, along with amplification or deletion of PDGFRA, MDM2, KIT, CDKN2Ap16INK4A, CDKN2Ap14ARF and CDKN2B. The E472D missense mutation of PDGFRB was identified for the first time in any tumor and was accompanied by elevated levels of activated/phosphorylated PDGFRB. The gene discussed is PDGFRB; the disease is cancer.