In addition to the results described above, various other ERβ-selective drugs such as ERB-041, 3,3′-diindolylmethane (DIM) should also be considered when exploring the roles of ERβ agonists in malignant glioma treatment [8, 9], although no reports have been published regarding their treatment effect on glioma. The gene discussed is ESR2; the disease is central nervous system cancer.