The first study that proposed the role of the IL-1β/miR-101/EZH2 axis in LC found that autocrine and paracrine IL-1β stimulated the downregulation of miR-101 in a Xuanwei LC cell line (XWLC-05), leading to EZH2 upregulation, which in turn triggered tumorigenesis [16]. This evidence concerns the gene IL1B and laryngotracheoesophageal cleft.