Moreover, Gradilone, A et al. evaluated the expression of vimentin, fibronectin and ALDH 1 in CTCs from 92 female patients with breast cancer and found that 91% (10/11) of the triple-positive samples (ALDH1/vimentin/ fibronectin) were isolated from patients with stage IV disease, and the expression of ALDH 1 by CTCs significantly correlated with the stage of disease [123]. The gene discussed is ALDH1A1; the disease is breast cancer.