Multivariate logistic regression analysis demonstrated that plasma Fib level was independently associated with high GS after adjusting for age, body mass index (BMI), current smoking, hypertension, family history of CAD, high-sensitivity C-reactive protein (hs-CRP), glucose, HbA1c, and various lipid parameters (OR=2.173, 95% CI 1.011–4.670, P=0.047). The gene discussed is FBL; the disease is hypertensive disorder.