As a short half-life protein and indicator of procoagulant state which was swiftly consumptions, circulating Fib was not only involved in acute phase of acutecoronary syndrome (ACS) but also participated in chronic inflammatory response, which could accelerate the progress of atherosclerosis, and subsequently lead to the development of clinical CAD [13, 29–33]. Here, FBL is linked to atherosclerosis.