Although association between E-cadherin expression and ovarian cancer prognosis has been reported, the contributions of this meta-analysis are as follows: (I) more articles (16 studies vs. 9 studies) and subjects were included in our meta-analysis to provide rigorous evidence compared to a previous meta-analysis conducted in 2012 [22]; (II) stratified analyses of HR estimation, study quality, score criteria, and histological type were conducted to explore heterogeneity; and (III) associations between decreased E-cadherin expression and clinicopathological characteristics were evaluated. The gene discussed is CDH1; the disease is ovarian cancer.