Reduced E-cadherin expression has significant association with residual tumor (≥ 1cm vs. < 1cm, HR = 2.72, 95% CI: 1.99–3.72), E-cadherin membranous staining (negative vs. positive, HR = 1.47, 95% CI: 1.01–2.14), and surgery (suboptimal vs. optimal, HR=3.21, 95% CI: 1.19–8.67). The gene discussed is CDH1; the disease is neoplasm.