In HCC patients, a low serum IGF1 level was predictive of a shorter TTP (OR, 2.74; 95% CI, 1.92–3.90) and poorer OS (OR, 2.20; 95% CI, 1.81–2.68), with no heterogeneity (I-square = 0), irrespective of the grade of hepatic dysfunction, which is consistent with previous reports [6, 13, 15, 26–29]. Here, IGF1 is linked to hepatocellular carcinoma.