IGFBP3 and hepatocellular carcinoma: Additionally, we assessed the association between the IGFI/ IGFBP3 molar ratio and the risk of HCC, odds ratio (OR, 1.311; 95% confidence interval (CI), 0.761–2.260; I-square, 46.86; p = 0.130) not showing a significant increase of IGF-I/IGFBP3 ratio in HCC incidence (data not shown).