According to our meta-analysis, negative E-cadherin expression in OC is correlated with FIGO stage (I/II vs. III/IV, pooled OR = 0.42, 95% CI = 0.31–0.57, p < 0.001), tumor grade (1/2 vs. 3, pooled OR = 0.48, 95% CI = 0.34–0.67, p < 0.001), metastasis (Absent vs. Present, pooled OR = 0.13, 95% CI = 0.07–0.26, p < 0.001), and with ovarian cancer recurrence (Absent vs. Present, pooled OR = 0.48, 95% CI = 0.29–0.79, p < 0.001). The gene discussed is CDH1; the disease is neoplasm.