The levels of IL-6 and TNF-α in AD mice treated with PLGA nanoparticle control were increased comparing to wild type mice, whereas NP-S1, NP-Cur, NP-S1-Cur and CRT-NP-S1-Cur significantly decreased IL-6 and TNF-α levels (Figure 7A and 7B). Here, TNF is linked to Alzheimer disease.