As shown in Figure 6E, we found that the levels of AKT, mTOR and 4E-BP1 phosphorylation were attenuated after CHERP depletion, which indicated that the AKT/mTOR/4E-BP1 pathway was involved in neuroblastoma cell apoptosis mediated by CHERP depletion. The gene discussed is MTOR; the disease is neuroblastoma.