CDH1 and cervical carcinoma: In cervical cancer, Zhao et al. demonstrated that levels of microRNA-122 (miR-212) and miR-132, both of which are from the same gene cluster, are reduced in cancerous tissues compared to adjacent normal tissues; furthermore, over-expression of miR-212/132 increased cell cycle arrest at the G1/S phase, inhibited cell proliferation, increased E-cadherin levels, decreased vimentin levels, and inhibited EMT, migration, and invasion in cervical cancer cells by targeting Smad2 [26].