It has been reported that simultaneous expression of CD34 and CD2 in leukemia cells is indicative of an immature immunophenotype of APL and is thought to be associated with the internal tandem duplication of the FLT3 gene (FLT3/ITD) [21, 22]; however, we found that these two markers played no role in the diagnosis of APL in our APL specific immunophenotypic combinations. This evidence concerns the gene CD2 and acute promyelocytic leukemia.