Furthermore, staining wild-type or GRP78 heterozygous breast tumors with CD68 (green) and CD80 (red) indicates that GRP78 heterozygousity increases the CD68+/CD80+ double positive cell infiltration into the breast tumor (Figure 6B), suggesting an elevated tumoral M1-like macrophage population. The gene discussed is HSPA5; the disease is breast neoplasm.