HSPA5 and neoplasm: In vivo targeting of GRP78 in tumor bearing female BALB/c mice demonstrated elevated M1-like IL-12p70, IL-1, and IL-6 circulating cytokines with a corresponding decrease in M2-like TARC, eotaxin, and RANTES chemokines (Figure 6A), suggesting that systematic inhibition of GRP78 leads to a pro-inflammatory M1-like cytokine shift [41].