Several other tumor markers have been reported as good complements to AFP and have been used in clinical diagnosis, including lens culinaris agglutinin reactive AFP (AFP-L3), des-γ-carboxy prothrombin (DCP) and Golgi protein 73 (GP73) [13–18], but they do not meet the clinical requirements for early stage HCC diagnosis. Here, ACE is linked to hepatocellular carcinoma.