Several other tumor markers have been reported as good complements to AFP and have been used in clinical diagnosis, including lens culinaris agglutinin reactive AFP (AFP-L3), des-γ-carboxy prothrombin (DCP) and Golgi protein 73 (GP73) [13–18], but they do not meet the clinical requirements for early stage HCC diagnosis. The gene discussed is AFP; the disease is hepatocellular carcinoma.