GPC3 and cancer: The overexpression of GPC3 was later observed in a variety of cancers, including metastatic colorectal carcinomas [5], alpha-fetoprotein-producing gastric carcinoma [6], hepatoblastoma [7], Wilms’ tumor [7], malignant melanoma [8], yolk sac tumor, choriocarcinoma [9], ovarian carcinoma [10], and pancreatic ductal adenocarcinoma [11].