Immunohistochemistry studies of these 36 HCCs (tumor regions) exhibited strong positive GPC3 staining in 25 and positive IGF-1R staining in 18 (Figure 1C), and the expression of GPC3 and IGF-1R was correlated (Figure 1D; p < 0.005 by Fisher's exact test). This evidence concerns the gene GPC3 and neoplasm.