It was showed that it was implicated in cancer metastasis indeed the phosphorylation of KARS at the Thr52 residue by p38MAPK, causes the dissociation from the cytosolic multi-tRNA synthetase complex and the following translocation to the plasma membrane, where it associates with a 67 kDa laminin receptor (p67LR) involved in migration and metastasis [30]. This evidence concerns the gene KARS1 and cancer.