It is of note that, in recent papers it was demonstrated that molecules able to interfere with STAT3 are able to overcome Vemurafenib resistance in melanoma cells [27] and that hyperactivation of CREB confers acquired resistance to to BRAFV600E inhibition in melanoma via upregulation of AEBP1 expression and consequent activation of NF-κB [28]. The gene discussed is AEBP1; the disease is melanoma.