CXCR4 and glioblastoma: Knock-down of endogenic MIF by siMIF, neutralizing ectogenic MIF by ISO-1 or blocking the CXCR4-AKT pathway disrupted the hypoxia-induced EMT, showing that the MIF-CXCR4 pathway plays a key role in hypoxia-induced EMT in GBM cells (Figure 5A, 5B, 5C).