Although previous reports suggested that LOXL2 expression may be related to CRC differentiation and stage [18, 19], the results of our clinical analysis showed a correlation between CRC metastasis rate and LOXL2 expression, which agrees with the results obtained in studies investigating LOXL2 roles in other cancer types [13–17], and the study examining the LOH locus in CRC patients with liver metastasis [20]. Here, LOXL2 is linked to cancer.