PTK2 and colorectal carcinoma: Other members of LOX family have been suggested to induce the activation of EMT, including LOX, which was reported to be involved in the development of CRC metastasis [24], through the activation of FAK/Src signaling pathway, which induces the EMT process, and the activation of the pathway induced by ECM remodeling, which may trigger the activation of cellular receptors, such as integrin.