LOXL2 and colorectal carcinoma: We observed that LOXL2-positive CRC cells have an increased migratory potential, in comparison with that of the LOXL2-negative cells; LOXL2 knockdown/ectopic expression was shown to affect this migratory potential in these cells in vitro, demonstrating that LOXL2 promotes the EMT process, while the results obtained by analyzing clinicopathological parameters strongly support the pro-metastatic role of LOXL2 in CRC progression.