Vinpocetine is a derivative of the alkaloid vincamine and has been used to treat cerebrovascular disorders and cognitive impairment in the clinic for many years.[28] As shown in a rat MCAO model, vinpocetine is a unique anti-inflammatory agent that increases the resistance of the brain to hypoxia and ischemic injury and protects against cerebral I/R injury by inhibiting the functional expression of NF-κB.[19, 29] Vinpocetine exerted an anti-inflammatory effect on cerebral I/R injury in both a mouse MCAO model and a microglia OGD model in this study. Here, NFKB1 is linked to Cognitive impairment.