Univariate Cox regression analysis showed that depth of invasion (P = 0.000), lymph node metastasis (P = 0.000), clinical TNM stage (P = 0.000), tumor size (P = 0.003), HSPC111 expression (P = 0.019), nuclear YAP1 expression (P = 0.000) and HSPC111/nuclear YAP1 expression (P = 0.000) were significantly correlated with overall survival in GC patients. The gene discussed is YAP1; the disease is gastric cancer.