Since mitochondrial Ca2+ uptake is essential for mitochondrial metabolic activity, we manipulated the expression of PRMT1 and UCP2, proteins known to affect the mitochondrial Ca2+ uptake machinery, to investigate their effect on human non-small-cell lung cancer cell lines A549, Calu-3 and H1299. This evidence concerns the gene PRMT1 and non-small cell lung carcinoma.