One might argue, that overexpression of MCU might lead to mitochondrial Ca2+ overload and apoptosis as in prostate cancer cells, but, breast cancer is well known for a strong upregulation of PRMT1 [21], also confirmed by our TCGA analysis, which might protect cancer cells from Ca2+ overload via MICU1 methylation. This evidence concerns the gene MICU1 and breast carcinoma.