Methylation of the mitochondrial Ca2+ uptake 1 (MICU1) [11], a protein controlling the activity of the mitochondrial Ca2+ uniporter (MCU) [12], by protein arginine methyl transferase 1 (PRMT1) causes a strong sensitivity loss of the mitochondrial Ca2+ uptake machinery in cancer cells and counteracts the risk of mitochondrial Ca2+ overload [13]. This evidence concerns the gene MCU and cancer.