In fact, CM generated by HCC-stimulated MSCs showed an increased capability to recruit fibroblasts, PBMNC and endothelial cells, probably due to an increase in chemokines such as CXCL8/IL-8, CXCL1-2-3/GRO and CXCL6/GCP-2. This evidence concerns the gene CXCL8 and hepatocellular carcinoma.