While mutant forms of the oncoprotein p53 as well as isocitrate dehydrogenase (IDH) are found in many low-grade gliomas [1, 2], mutations in epidermal growth factor receptor (EGFR) is present in 40% of GBM cases, the most common being the EGFRvIII mutation, which seen in approximately 25% of GBM [5]. The gene discussed is EGFR; the disease is glioblastoma.