TERC and cancer: TSCE was detected in both K14Cre;TRF2f/f;Terc-/- (54%) and K14Cre;TRF2+/+;Terc+/+ (44%) SCC cells (Figure 6E, 6F) which was also observed in Terc null (41%) and TRF2 null (48%) cancers (Supplementary Figure 4E, 4F).