Surprisingly PML protein colocalized at telomeres in both K14Cre;TRF2f/f;Terc-/- (51%) and K14Cre;TRF2+/+;Terc+/+ (45%) SCC cells (Figure 6C, 6D) which was also observed in Terc null (43%) and TRF2 null (49%) cancers (Supplementary Figure 4C, 4D). This evidence concerns the gene PML and cancer.