PRRT2 and glioblastoma: Glioblastoma was one of the first cancers profiled by the National Institutes of Health's Cancer Genome Atlas [42], and these efforts identified numerous promising targets including EGFR, VEGF, PDGFRs and PKC -- all targets that were observed to be frequently overexpressed in glioblastomas and for which overexpression frequently correlated inversely with prognosis.